The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Dec. 26, 2018
Kyowa Kirin Co., Ltd., Tokyo, JP;
Masahiro Ikeda, Tokyo, JP;
Shinpei Yamaguchi, Tokyo, JP;
Masumi Murakami, Tokyo, JP;
Hideyuki Onodera, Tokyo, JP;
KYOWA KIRIN CO., LTD., Tokyo, JP;
Abstract
An object of the present invention is to provide a novel IL-2 variant which has improved selectivity for IL-2Rand selectively activates Tregs. The present invention relates to an IL-2 variant, a method for producing the IL-2 variant, a composition and a therapeutic agent for an immune disease, comprising the IL-2 variant, a method for increasing selectivity of IL-2 for IL-2Rαβγ, a method for improving an affinity of IL-2 for an IL-2Rα subunit, a method of reducing an affinity of IL-2 for at least one of an IL-2Rβ subunit and an IL-2Rγ subunit, and a method for selectively activating regulatory T cells.