The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Apr. 22, 2021
Applicant:
Translate Bio, Inc., Lexington, MA (US);
Inventors:
Frank DeRosa, Lexington, MA (US);
Michael Heartlein, Lexington, MA (US);
Shrirang Karve, Lexington, MA (US);
Assignee:
TRANSLATE BIO, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2016.12); A61K 9/00 (2005.12); A61K 9/127 (2005.12); A61K 9/1272 (2024.12); A61K 38/17 (2005.12); A61K 47/28 (2005.12); A61K 47/60 (2016.12); A61K 47/69 (2016.12); A61K 48/00 (2005.12); A61P 11/12 (2005.12);
U.S. Cl.
CPC ...
A61K 47/554 (2017.07); A61K 9/0078 (2012.12); A61K 9/1272 (2012.12); A61K 38/1709 (2012.12); A61K 47/28 (2012.12); A61K 47/543 (2017.07); A61K 47/60 (2017.07); A61K 47/6911 (2017.07); A61K 48/0008 (2012.12); A61K 48/0033 (2012.12); A61K 48/0041 (2012.12); A61K 48/0066 (2012.12); A61K 48/0075 (2012.12); A61P 11/12 (2017.12);
Abstract
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids.