The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Oct. 01, 2023
Centro DE Inmunología Molecular, Havana, CU;
Luis Enrique Fernández Molina, Havana, CU;
Belinda Sánchez Ramírez, Havana, CU;
Audry Fernández Gómez, Havana, CU;
Gretchen Bergado Báez, Havana, CU;
Circe Mesa Pardillo, Havana, CU;
Lisset Chao García, Sancti Spiritus, CU;
Narjara González Suárez, Havana, CU;
Dayana Pérez Martínez, Havana, CU;
Diana Rosa Hernández Fernández, Havana, CU;
Mabel Cruz Rodríguez, Havana, CU;
Ángel Alexis Manso Vargas, Havana, CU;
Vicente Guillermo Verez Bencomo, Havana, CU;
Blanca Idelmis Tolón Murguía, Havana, CU;
Miguel Antonio López López, Havana, CU;
Jesús Arturo Junco Barranco, Camagüey, CU;
Centro de Inmunología Molecular, Havana, CU;
Abstract
This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) ofin solutions containing fully synthetic variants of the GM3 ganglioside.