The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Apr. 15, 2021
Applicant:
Vlp Therapeutics, Inc., Wilmington, DE (US);
Inventors:
Wataru Akahata, Kensington, MD (US);
Jonathan F. Smith, Redwood City, CA (US);
Ryuji Ueno, Easton, MD (US);
Assignee:
VLP Therapeutics, Inc., Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/215 (2005.12); C07K 14/165 (2005.12); C07K 14/18 (2005.12);
U.S. Cl.
CPC ...
A61K 39/215 (2012.12); C07K 14/165 (2012.12); C07K 14/1808 (2012.12); C07K 2319/02 (2012.12); C07K 2319/03 (2012.12); C12N 2770/20034 (2012.12); C12N 2770/36141 (2012.12);
Abstract
Provided herein is an isolated polynucleotide, which encodes alphavirus non-structural proteins nsp1, nsp2, nsp3 and nsp4 and a polypeptide comprising a coronavirus protein fused to a signal sequence and/or transmembrane domain. The coronavirus protein may be the receptor binding domain of the S1 subunit of coronavirus spike (S) protein. The polynucleotide such as RNA is useful for as a vaccine against coronavirus infection, especially, COVID-19 infection.