The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Feb. 19, 2020
Consejo Nacional DE Investigaciones Científicas Y Técnicas (Conicet), Ciudad Autónoma de Buenos Aires, AR;
Universidad Nacional DE Quilmes, Pcia. de Buenos Aires, AR;
Universidad DE Buenos Aires, Ciudad Autónoma de Buenos Aires, AR;
Ernesto J. Podestá, Ciudad Autónoma de Buenos Aires, AR;
Paula M. Maloberti, Ciudad Autónoma de Buenos Aires, AR;
Ulises D. Orlando, Pcia. de Buenos Aires, AR;
Ana F. Castillo, Pcia. de Buenos Aires, AR;
Angela R. Solano, Ciudad Autónoma de Buenos Aires, AR;
Pablo Lorenzano Menna, Prov. de Buenos Aires, AR;
Daniel E. Gomez, Pcia. de Buenos Aires, AR;
Sergio H. Szajnman, Ciudad Autónoma de Buenos Aires, AR;
Jessica G. Prada, Pcia. de Buenos Aires, AR;
Juan B. Rodriguez, Ciudad Autónoma de Buenos Aires, AR;
CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET), Buenos Aires, AR;
UNIVERSIDAD NACIONAL DE QUILMES, Buenos Aires, AR;
UNIVERSIDAD DE BUENOS AIRES, Buenos Aires, AR;
Abstract
A new compound of formula A for the treatment of aggressive and/or resistant tumors expressing acyl-CoA synthetase 4 (ACSL4) and/or depending on steroids action. More particularly, the compound of the present invention inhibits tumor growth in ACSL4-expressing breast and prostate cancers, inhibits steroid synthesis and sensitizes cells towards chemotherapeutic and hormone therapy agents. Pharmaceutical compositions comprising the ACSL4-inhibitory compound of the invention, pharmaceutical combinations thereof with other anticancer agents and use in therapy.