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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12275961 B1

PDFFull Text
Date of Patent:
Apr. 14, 2025

Filed:

Jan. 15, 2020

Method for utilizing engineered dendritic cells to induce gut-homing regulatory t cells and treat gut inflammation

Applicant:

Loma Linda University, Loma Linda, CA (US);

Inventors:

Xiaolei Tang, Loma Linda, CA (US);

David J. Baylink, Redlands, CA (US);

K.-H. William Lau, Redlands, CA (US);

Michael Walter, Loma Linda, CA (US);

Assignee:

LOMA LINDA UNIVERSITY, Loma Linda, CA (US);

Attorney:

Womble Bond Dickinson (US) LLP

Primary Examiner:

Michael D Burkhart

Int. Cl.
CPC ...
C12N 5/0784 (2009.12); A61K 38/44 (2005.12); A61K 39/00 (2005.12); A61K 48/00 (2005.12); C12N 9/02 (2005.12); C12P 19/34 (2005.12);
U.S. Cl.
CPC ...
C12N 9/0008 (2012.12); A61K 38/44 (2012.12); A61K 39/4615 (2023.04); A61K 39/4621 (2023.04); A61K 39/4622 (2023.04); A61K 39/46433 (2023.04); A61K 39/464454 (2023.04); A61K 48/00 (2012.12); C12N 9/0073 (2012.12); C12P 19/34 (2012.12); C12Y 102/01036 (2012.12); C12Y 114/13013 (2012.12); A61K 2239/31 (2023.04); A61K 2239/38 (2023.04);
Abstract

Gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme.

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