The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2025
Filed:
Jun. 26, 2019
Applicants:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Lincoln University, Lincoln, NZ;
Inventors:
Steven James Gray, Southlake, TX (US);
David Palmer, Christchurch, NZ;
Nadia Mitchell, Christchurch, NZ;
Assignees:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Lincoln University, Lincoln, NZ;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2005.12); A61P 25/28 (2005.12); C12N 15/86 (2005.12); C07H 21/04 (2005.12);
U.S. Cl.
CPC ...
C12N 15/86 (2012.12); A61P 25/28 (2017.12); C07H 21/04 (2012.12); C12N 15/85 (2012.12); C12N 2750/14143 (2012.12); C12N 2830/008 (2012.12); C12N 2830/50 (2012.12);
Abstract
This invention relates to polynucleotides comprising optimized CLN5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLN5 gene or aberrant activity of a CLN5 gene product in the subject, such as CLN5 disease.