The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2025
Filed:
Apr. 14, 2021
Applicants:
Research Institute AT Nationwide Children's Hospital, Columbus, OH (US);
The Trustees of Columbia University IN the City of New York, New York, NY (US);
Inventors:
Scott Quenton Harper, Powell, OH (US);
Wayne N. Frankel, Katonah, NY (US);
Assignees:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US);
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2009.12); A61K 31/713 (2005.12); C12N 15/86 (2005.12);
U.S. Cl.
CPC ...
C12N 15/1138 (2012.12); A61K 31/713 (2012.12); C12N 15/86 (2012.12); C12N 2310/14 (2012.12); C12N 2750/14143 (2012.12);
Abstract
RNA interference-based methods and products for inhibiting the expression of pathogenic dynamin-1 variants are provided. Delivery vehicles such as recombinant adeno-associated viruses deliver DNAs encoding RNAs that inhibit the expression of the dynamin-1 variants. The methods treat, for example, developmental and epileptic encephalopathies.