The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2025
Filed:
Sep. 18, 2019
Applicant:
Xlifesc, Ltd., Guangdong, CN;
Inventors:
Assignee:
XLIFESC, LTD., Guangdong, CN;
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2005.12); C07K 16/28 (2005.12); A61K 38/00 (2005.12);
U.S. Cl.
CPC ...
C07K 14/7051 (2012.12); C07K 16/2809 (2012.12); A61K 38/00 (2012.12); C07K 2319/03 (2012.12);
Abstract
Provided in the present invention is a T cell receptor (TCR) having the property of binding to a FMNKFIYEI-HLA A0201 complex; and the binding affinity of the TCR to the FMNKFIYEI-HLA A0201 complex is at least 2 times the binding affinity of the wild-type TCR to the FMNKFIYEI-HLA A0201 complex. Also provided in the present invention is a fusion molecule of such TCRs with therapeutic agents. Such TCRs can be used alone or in combination with therapeutic agents, so as to target tumor cells presenting the FMNKFIYEI-HLA A0201 complex.