The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2025

Filed:

Oct. 10, 2021
Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Julia Regina Grimm, Mainz, DE;

Katrin Baer, Mainz, DE;

Albert Josef Barta, Warthausen, DE;

Gisela Bodenbach, Niederburg, DE;

Joe Ju Gao, Southbury, CT (US);

Fredrik Lars Nordstrom, Ridgefield, CT (US);

Michael Wiese, Gensingen, DE;

Bing-Shiou Yang, Southbury, CT (US);

Manabu Nakatani, Hyogo, JP;

Masashi Adachi, Mino, JP;

Kenji Egusa, Ikeda, JP;

Roman Christian Messerschmid, Wiesbaden, DE;

Daniela Maria Schroeder, Biberach an der Riss, DE;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/04 (2005.12); A61K 9/20 (2005.12); A61K 31/422 (2005.12);
U.S. Cl.
CPC ...
C07D 413/04 (2012.12); A61K 9/2013 (2012.12); A61K 9/2018 (2012.12); A61K 9/2054 (2012.12); A61K 9/2095 (2012.12); A61K 31/422 (2012.12); C07B 2200/13 (2012.12);
Abstract

The invention describes a process for reworking of a crystallization product comprising drying and homogenization. The crystallization product is crystalline [5-(methylsulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hex-3-yl}methanone. The product is dried in a tray dryer or in a pan dryer and subsequently homogenized.


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