The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2025
Filed:
Feb. 02, 2023
Applicant:
Dermavant Sciences Gmbh, Basel, CH;
Inventors:
Ian Paul Andrews, King of Prussia, PA (US);
Nicholas Calandra, Cambridge, MA (US);
Tyler Andrew Davis, Research Triangle Park, NC (US);
Ravinder Reddy Sudini, King of Prussia, PA (US);
Assignee:
DERMAVANT SCIENCES GMBH, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 39/08 (2005.12); A61K 31/05 (2005.12); C07C 37/00 (2005.12); C07C 37/07 (2005.12); C07C 45/54 (2005.12); C07C 45/63 (2005.12); C07C 45/72 (2005.12); C07C 50/24 (2005.12); C07C 51/09 (2005.12); C07C 51/38 (2005.12); C07C 59/353 (2005.12); C07C 67/03 (2005.12); C07C 67/293 (2005.12); C07C 67/343 (2005.12); C07C 69/716 (2005.12);
U.S. Cl.
CPC ...
C07C 39/08 (2012.12); C07C 37/002 (2012.12); C07C 37/07 (2012.12); C07C 45/54 (2012.12); C07C 45/63 (2012.12); C07C 45/72 (2012.12); C07C 50/24 (2012.12); C07C 51/09 (2012.12); C07C 51/38 (2012.12); C07C 59/353 (2012.12); C07C 67/03 (2012.12); C07C 67/293 (2012.12); C07C 67/343 (2012.12); C07C 69/716 (2012.12); A61K 31/05 (2012.12);
Abstract
The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.