The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2025
Filed:
May. 13, 2018
Applicant:
Riken, Wako, JP;
Inventors:
Shigeyuki Yokoyama, Yokohama, JP;
Tetsuya Hori, Yokohama, JP;
Assignee:
RIKEN, Wako, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 257/18 (2005.12); C07C 211/33 (2005.12); C07C 211/34 (2005.12); C07C 211/39 (2005.12); C07C 211/44 (2005.12); C07C 233/57 (2005.12); C07C 233/64 (2005.12); C07C 257/16 (2005.12); C07C 259/16 (2005.12); C07C 259/18 (2005.12); C07C 279/16 (2005.12); C07C 279/18 (2005.12); C07C 279/26 (2005.12); C07D 403/12 (2005.12); C07H 19/167 (2005.12); C07K 16/28 (2005.12); C12N 15/115 (2009.12);
U.S. Cl.
CPC ...
C07C 257/18 (2012.12); C07C 211/33 (2012.12); C07C 211/34 (2012.12); C07C 211/39 (2012.12); C07C 211/44 (2012.12); C07C 233/57 (2012.12); C07C 233/64 (2012.12); C07C 257/16 (2012.12); C07C 259/16 (2012.12); C07C 259/18 (2012.12); C07C 279/16 (2012.12); C07C 279/18 (2012.12); C07C 279/26 (2012.12); C07D 403/12 (2012.12); C07H 19/167 (2012.12); C07K 16/28 (2012.12); C12N 15/115 (2012.12);
Abstract
To provide a novel class-A GPCR antagonist, a production method therefor, or a novel compound that interacts with a Na-water cluster binding site of a class-A GPCR. Used is a compound or a salt thereof comprising a structure comprising a class-A GPCR-binding compound linked to a functional group that can bind to a Na-water cluster binding site of the class-A GPCR. Also used is a method for producing a class-A GPCR antagonist, comprising the step of linking one compound with another compound that can bind to a Na-water cluster binding site of the class-A GPCR.