The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2025

Filed:

Aug. 21, 2019
Applicants:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Regents of the University of Minnesota, Minneapolis, MN (US);

Inventors:

Lotfi Abou-Elkacem, Houston, TX (US);

Juergen Karl Willmann, Stanford, CA (US);

Benjamin J. Hackel, Edina, MN (US);

Lawrence Arthur Stern, Monrovia, CA (US);

Patrick Samuel Lown, Minneapolis, MN (US);

Amelie Margarete Marianne Lutz, Stanford, CA (US);

Rakesh Kumar Bam, Menlo Park, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2005.12); A61K 9/00 (2005.12); A61K 47/68 (2016.12); A61K 49/22 (2005.12); A61P 35/00 (2005.12); C07K 16/28 (2005.12); A61K 39/00 (2005.12);
U.S. Cl.
CPC ...
A61K 49/221 (2012.12); A61K 9/0019 (2012.12); A61K 47/6849 (2017.07); A61K 49/223 (2012.12); A61P 35/00 (2017.12); C07K 16/2827 (2012.12); A61K 2039/505 (2012.12); C07K 2317/92 (2012.12); C07K 2318/20 (2012.12);
Abstract

Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity. The affibodies can be conjugated to contrast agents, including without limitation microbubbles for contrast-enhanced ultrasound imaging


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