The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2025
Filed:
Jan. 27, 2022
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Kara Olson, White Plains, NY (US);
Olga Sineshchekova, Pleasantville, NY (US);
Eric Smith, New York, NY (US);
Chia-Yang Lin, Scarsdale, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2005.12); A61K 35/17 (2014.12); A61K 38/17 (2005.12); A61P 35/00 (2005.12); A61P 37/06 (2005.12);
U.S. Cl.
CPC ...
A61K 39/3955 (2012.12); A61K 35/17 (2012.12); A61K 38/1774 (2012.12); A61K 39/39558 (2012.12); A61P 35/00 (2017.12); A61P 37/06 (2017.12);
Abstract
The present invention provides compositions and methods for treating cancer and inhibiting cytokine release syndrome (CRS). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a CD40 antagonist or a CAR-T cell expressing a CD40 antagonist in combination with a therapeutically effective amount of a CD3 multispecific antigen binding molecule.