The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2025
Filed:
Apr. 25, 2023
Cornell University, Ithaca, NY (US);
Gareth R. Tibbs, Staten Island, NY (US);
Peter A. Goldstein, Hartsdale, NY (US);
Anthony A. Sauve, New Rochelle, NY (US);
Rajendra Uprety, Cary, NC (US);
James David Warren, Jr., New York, NY (US);
Rebecca L. Joyce, Newark, NJ (US);
Dipti N. Barman, Rutherford, NJ (US);
Cornell University, Ithaca, NY (US);
Abstract
Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.