The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2025

Filed:

Aug. 10, 2022
Applicant:

Brown University, Providence, RI (US);

Inventors:

Kimani Toussaint, Providence, RI (US);

Rutendo Jakachira, Providence, RI (US);

Mbaye Diouf, Providence, RI (US);

Joshua Burrow, Providence, RI (US);

Zixi Lin, Providence, RI (US);

Assignee:

BROWN UNIVERSITY, Providence, RI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/1455 (2005.12); A61B 5/00 (2005.12); A61B 5/02 (2005.12); A61B 5/021 (2005.12); A61B 5/024 (2005.12); A61B 5/026 (2005.12); A61B 5/08 (2005.12);
U.S. Cl.
CPC ...
A61B 5/14552 (2012.12); A61B 5/14558 (2012.12); A61B 5/7275 (2012.12); A61B 5/02007 (2012.12); A61B 5/02028 (2012.12); A61B 5/021 (2012.12); A61B 5/02444 (2012.12); A61B 5/0261 (2012.12); A61B 5/0803 (2012.12); A61B 5/0816 (2012.12); A61B 2560/0443 (2012.12); A61B 2560/0462 (2012.12);
Abstract

A cardiovascular variability parameter can be detected independent of the relative absorption contribution of melanin in biological tissue. A light source and a polarization shaping device can illuminate a biological tissue with a polarized light having an inhomogeneous optical polarization wavefront. A polarization analyzer can receive the polarized light after it has interacted with the biological tissue and output a first and second polarization state. A detection device can have a light detector for detecting the first and second polarization state and at least a processor for detecting data related to the first and second polarization states, determining relative absorptions contributions of superficial and deep components of the biological tissue based on the first and second polarization states, and determining the cardiovascular variability parameter based on the relative absorption contributions of the superficial and deep components.


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