The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
Jan. 14, 2022
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Jeffrey R. Brender, Washington, DC (US);
James B. Mitchell, Damascus, MD (US);
Kazutoshi Yamamoto, North Bethesda, MD (US);
Shun Kishimoto, Rockville, MD (US);
Jeeva P. Munasinghe, Rockville, MD (US);
Hellmut Merkle, Bethesda, MD (US);
Murali K. Cherukuri, Potomac, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human, Services Bethesda, MD;
Abstract
Kinetic monitoring of in vivo metabolism of labelled tracers is based on singular value decomposition or Tucker Decomposition of magnetic resonance spectral image data. Data decomposition is used in conjunction with rank reduction to improve signal-to-noise ratio. Rank reduction can be applied in one or more of a spectral, spatial, or temporal dimension. Rank is generally reduced based on a number of expected analytes/metabolites or fit of measured data to a model.