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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12270024 B1

PDFFull Text
Date of Patent:
Apr. 08, 2025

Filed:

Jun. 28, 2022

Engineered microorganisms expressing acetoacetyl-coa reductase variants and methods for increasing proportion of 3-hydroxyhexanoic acid in pha

Applicant:

Shenzhen Bluepha Biosciences Co., Ltd., Guangdong, CN;

Inventors:

Jin Yin, Guangdong, CN;

Yu Wang, Guangdong, CN;

Jiajia Li, Guangdong, CN;

Jie Hou, Guangdong, CN;

Liang Zou, Guangdong, CN;

Zixian Chen, Guangdong, CN;

Assignee:

SHENZHEN BLUEPHA BIOSCIENCES CO., LTD., Guangdong, CN;

Attorney:

Mendelsohn Dunleavy P.C.

Primary Examiner:

Louise W Humphrey

Assistant Examiner:

Rachel Emily Martin

Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12N 9/04 (2006.01); C12N 9/10 (2006.01); C12N 9/88 (2006.01); C12N 15/74 (2006.01); C12N 15/90 (2006.01); C12P 7/625 (2022.01); C12R 1/01 (2006.01);
U.S. Cl.
CPC ...
C12N 1/20 (2013.01); C12N 9/0006 (2013.01); C12N 9/1029 (2013.01); C12N 9/88 (2013.01); C12N 15/74 (2013.01); C12N 15/90 (2013.01); C12P 7/625 (2013.01); C12N 2510/00 (2013.01); C12R 2001/01 (2021.05); C12Y 101/01036 (2013.01); C12Y 402/01119 (2013.01);
Abstract

The present invention relates to the technical field of microorganisms, and specifically to engineered microorganisms expressing acetoacetyl-CoA reductase variants and methods for increasing the proportion of 3-hydroxyhexanoic acid in PHA. The acetoacetyl-CoA reductase variants and their coding genes provided by the present invention can significantly increase the proportion of 3-hydroxyhexanoic acid in PHA produced by strains; the proportion of 3-hydroxyhexanoic acid in PHA produced by the engineeredconstructed utilizing the acetoacetyl-CoA reductase variants and their coding genes provided by the present invention is significantly increased, which provides new genes and strain resources for strains producing poly(3-hydroxybutyrate-co-3-10 the development of engineered hydroxyhexanoate) with high proportion of 3-hydroxyhexanoic acid.

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