The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
Oct. 03, 2018
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventor:
Kenneth Walker, Newbury Park, CA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 19/00 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C07K 19/00 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 14/47 (2013.01); C07K 16/00 (2013.01); C07K 16/28 (2013.01); C07K 16/2878 (2013.01); C07K 2317/35 (2013.01); C07K 2319/00 (2013.01); C12N 15/63 (2013.01);
Abstract
The present invention relates to transthyretin (TTR) fusions useful in the dimerization and tetramerization of antibodies and antibody fragments, such as Fabs. The TTR fusions proteins described herein are particularly useful in increasing antibody avidity and in enhancing antigen clustering. Methods for treating diseases using the fusion proteins of the present invention are described herein.