The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
Dec. 23, 2021
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventor:
Denise L. Faustman, Boston, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 38/19 (2006.01); A61K 39/395 (2006.01); A61P 37/06 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 38/191 (2013.01); A61K 39/3955 (2013.01); A61P 37/06 (2018.01); G01N 33/6854 (2013.01); C07K 2317/34 (2013.01); C07K 2317/622 (2013.01); C07K 2317/75 (2013.01); C07K 2317/92 (2013.01); G01N 2333/7151 (2013.01);
Abstract
The invention provides agonistic TNFR2 antibodies and antigen-binding fragments thereof and encompasses the use of these antibodies as therapeutics to promote the proliferation of regulatory T cells (T-reg) for the treatment of immunological diseases. Antibodies of the invention can be used to potentiate the T-reg-mediated deactivation of self- and allergen-reactive T- and B-lymphocytes, and can thus be used to treat a wide variety of indications, including autoimmune diseases, allergic reactions, asthma, graft-versus-host disease, and allograft rejection, among others.