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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12269886 B1

PDFFull Text
Date of Patent:
Apr. 08, 2025

Filed:

Apr. 19, 2021

Tetravalent bispecific antibody against pd-1 and pd-l1

Applicant:

Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd., Shanghai, CN;

Inventors:

Zhenping Zhu, Shanghai, CN;

Jie Zhao, Shanghai, CN;

Haomin Huang, Shanghai, CN;

Mengying Xia, Shanghai, CN;

Assignee:

Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd., Shanghai, CN;

Attorneys:

Morse, Barnes-Brown & Pendleton, P.C.

Martin Z. Zhang

Russell L. Widom

Primary Examiner:

Hong Sang

Assistant Examiner:

Carol Ann Chase

Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C12N 5/10 (2006.01); C12N 15/00 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2827 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C12N 5/10 (2013.01); C12N 15/00 (2013.01); C12N 15/11 (2013.01); C12N 2510/00 (2013.01); C12N 2800/00 (2013.01);
Abstract

Provided are an antibody that binds to human PD-L1, and a tetravalent bispecific antibody against PD-1 and PD-L1 constructed based on the antibody that binds to human PD-L1. The tetravalent bispecific antibody requires no Fc modification, has no mismatch problems, and the preparation method thereof is simple. The biological activities and physical and chemical properties of the tetravalent bispecific antibody are similar with or even better than those of the monoclonal antibodies.

Find Patent Forward Citations

Zhu, Zhenping. (2025). Tetravalent bispecific antibody against pd-1 and pd-l1 (U.S. Patent No. 12269886). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12269886

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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