The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
Dec. 13, 2023
Immatics Biotechnologies Gmbh, Tuebingen, DE;
Meike Hutt, Tuebingen, DE;
Felix Unverdorben, Tuebingen, DE;
Sebastian Bunk, Tuebingen, DE;
Dominik Maurer, Tuebingen, DE;
Martin Hofmann, Tuebingen, DE;
Gabriele Pszolla, Tuebingen, DE;
Sara Yousef, Tuebingen, DE;
Claudia Wagner, Tuebingen, DE;
Frank Schwoebel, Tuebingen, DE;
Heiko Schuster, Tuebingen, DE;
Immatics Biotechnologies GmbH, Tübingen, DE;
Abstract
The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.