The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
May. 17, 2022
Applicant:
Autolus Limited, London, GB;
Inventors:
Assignee:
AUTOLUS LIMITED, London, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 39/00 (2006.01); C07K 14/71 (2006.01); C07K 14/715 (2006.01); C07K 14/725 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464412 (2023.05); A61K 39/464413 (2023.05); A61K 39/464471 (2023.05); A61K 39/464495 (2023.05); A61K 48/005 (2013.01); C07K 14/71 (2013.01); C07K 14/715 (2013.01); C12N 15/86 (2013.01); A61K 2239/11 (2023.05); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/47 (2023.05); C07K 2319/03 (2013.01); C12N 2740/16043 (2013.01); C12N 2800/40 (2013.01);
Abstract
There is provided method for making a cell composition which comprises step of transducing a population of cells with a mixture of at least two viral vectors, wherein at least one vector comprises a nucleic acid sequence which encodes a chimeric antigen receptor (CAR); and wherein at least one vector comprises a nucleic acid encoding an activity modulator which modulates the activity of the CAR, of a cell expressing the CAR, or of a target cell. There is also provided a cell composition made by such a method and its use in the treatment of diseases such as cancer.