The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
Sep. 20, 2019
Innovent Biologics (Suzhou) Co., Ltd., Jiangsu, CN;
Lishan Kang, Jiangsu, CN;
Chunyin Gu, Jiangsu, CN;
Fenggen Fu, Jiangsu, CN;
Shuaixiang Zhou, Jiangsu, CN;
Xinzhen Shi, Jiangsu, CN;
Junjian Liu, Jiangsu, CN;
INNOVENT BIOLOGICS (SUZHOU) CO., LTD., Jiangsu, CN;
Abstract
The present invention relates to a novel interleukin-2 (IL-2) mutant protein and use thereof. In particular, the present invention relates to an IL-2 mutant protein with reduced IL-2Rα receptor binding ability and/or increased IL-2Rβ receptor binding ability compared with the wild-type IL-2. The present invention further provides a fusion protein and an immunoconjugate comprising the IL-2 mutant protein, a nucleic acid encoding the IL-2 mutant protein, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-2 mutant protein, a pharmaceutical composition comprising the IL-2 mutant protein, and therapeutic use of the mutant protein.