The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 08, 2025

Filed:

Aug. 06, 2021
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Jeremy J. Clemens, San Diego, CA (US);

Brett C. Bookser, San Diego, CA (US);

Thomas Cleveland, San Marcos, CA (US);

Timothy R. Coon, Carlsbad, CA (US);

Michel Gallant, Pierrefonds, CA;

Peter Diederik Jan Grootenhuis, Del Mar, CA (US);

Sara Sabina Hadida Ruah, La Jolla, CA (US);

Julie Laterreur, San Diego, CA (US);

Vito Melillo, Escondido, CA (US);

Mark Thomas Miller, Rancho Santa Fe, CA (US);

Prasuna Paraselli, San Diego, CA (US);

Yeeman K. Ramtohul, Pierrefonds, CA;

Thumkunta Jagadeeswar Reddy, Pierrefonds, CA;

Claudio Sturino, Ile Bizard, CA;

Lino Valdez, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Minson Baek, San Diego, CA (US);

William Schulz Bechara, Laval, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/18 (2006.01); A61K 45/06 (2006.01); C07D 213/26 (2006.01); C07D 271/10 (2006.01);
U.S. Cl.
CPC ...
C07D 498/18 (2013.01); A61K 45/06 (2013.01);
Abstract

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.


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