The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
Jan. 16, 2019
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Sudipta Mahajan, Framingham, MA (US);
Marc Saul Weinberg, Encinitas, CA (US);
Diego Sebastian D'Astolfo, San Diego, CA (US);
Kevin M. Cottrell, Cambridge, MA (US);
Mark A. Morris, Somerville, MA (US);
John Patrick Maxwell, Hingham, MA (US);
VERTEX PHARMACEUTICALS INCORPORATED, Boston, MA (US);
Abstract
Compounds, methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNA-PK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNA-PK inhibitor disclosed herein.