The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 08, 2025

Filed:

Feb. 26, 2021
Applicant:

Cellix Limited, Dublin, IE;

Inventors:

Dmitry Kashanin, Dublin, IE;

Vivienne Williams, Dublin, IE;

Dhruv Gandhi, County Dublin, IE;

Assignee:

CELLIX LIMITED, Dublin, IE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 27/04 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502784 (2013.01); G01N 27/041 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/087 (2013.01);
Abstract

A system to determine the transfection status of at least one cell in a population of cells includes a fluidic device comprising a microfluidic channel and a detection zone comprising a detection electrode module comprising two electrodes configured to detect electrical impedance between the electrodes transversely across the channel in the detection zone; corresponding to a cell passing the detection zone, a pump fluidically coupled to the fluidic device and configured to pump the population of cells in a carrier liquid along the microfluidic channel, and a processor operatively coupled to the detection electrode module and configured to detect a change in electrical impedance corresponding to a cell passing the detection zone, compare the change in electrical impedance with a reference change in electrical impedance corresponding to a cell of known transfection status, and calculate the transfection status of the cell based on the comparison.


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