The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 08, 2025

Filed:

May. 27, 2020
Applicant:

Ustav Organicke Chemie a Biochemie Av CR V.v.i., Prague, CZ;

Inventors:

Miloslav Polasek, Prague, CZ;

Jan Kretschmer, Prague, CZ;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/10 (2006.01); A61K 49/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07F 5/00 (2006.01); C07K 5/078 (2006.01);
U.S. Cl.
CPC ...
A61K 49/106 (2013.01); A61K 49/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07F 5/003 (2013.01); C07K 5/06139 (2013.01);
Abstract

Cyclen based compounds of general formula (I) are disclosed. X is nitrogen and Y, Z are —CH—, or X, Z are —CH— and Y is nitrogen, or X, Y are —CH— and Z is nitrogen. Ris independently selected from H; COOH; benzyloxycarbonyl; fluorenylmethyloxycarbonyl; tert-butoxycarbonyl; methylcarbonyl; trifluoromethylcarbonyl; benzyl; triphenylmethyl; tosyl; mesyl; benzyloxymethyl; phenylsulfonyl; ethoxycarbonyl; 2,2,2-trichloroethyloxycarbonyl; methoxycarbonyl; methoxymethyloxycarbonyl; Ris selected from H; methylcarbonyl; tert-butyldimethylsilyl; (C1-C4)alkyl; Ris independently selected from H; (C1-C6)alkyl.


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