The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 08, 2025

Filed:

May. 25, 2019
Applicant:

Kartos Therapeutics, Inc., Redwood City, CA (US);

Inventor:

Wayne Rothbaum, Delray Beach, FL (US);

Assignee:

Kartos Therapeutics, Inc., Redwood City, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/451 (2006.01); A61K 9/00 (2006.01); A61K 31/706 (2006.01); A61K 38/21 (2006.01); A61K 45/06 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/451 (2013.01); A61K 9/0019 (2013.01); A61K 31/706 (2013.01); A61K 38/212 (2013.01); A61K 45/06 (2013.01); A61P 35/02 (2018.01);
Abstract

Therapeutic methods and pharmaceutical compositions for treating a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis, are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a combination of a compound of Formula (I) or Formula (II) with a therapeutic agent selected from the group consisting of a JAK inhibitor, an IDH inhibitor, a PD-1 inhibitor, a PD-L1 inhibitor, a PD-L2 inhibitor, an interferon, a PI3K inhibitor, an AKT inhibitor, an mTOR inhibitor, a nucleoside analog, and combinations thereof.


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