The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2025
Filed:
Apr. 02, 2021
Rensselaer Polytechnic Institute, Troy, NY (US);
Otsuka Pharmaceutical Factory, Inc., Naruto, JP;
Kirin Biomaterials Co., Ltd., Tokyo, JP;
Kenta Fukunaga, Tokyo, JP;
Aki Nishibara, Tokyo, JP;
Ryosuke Kato, Tokyo, JP;
Masahiro Kuratsu, Tokyo, JP;
Mikiro Hayashi, Tokyo, JP;
Shin-ichi Hashimoto, Tokyo, JP;
RENSSELAER POLYTECHNIC INSTITUTE, Troy, NY (US);
OTSUKA PHARMACEUTICAL FACTORY, INC., Naruto, JP;
KIRIN BIOMATERIALS CO., LTD., Tokyo, JP;
Abstract
The invention provides a method for producing sulfated polysaccharides by reacting a PAPS production/regeneration system utilizing the metabolic activity of a microorganism or a treated matter thereof with a microorganism expressing a sulfation enzyme or a treated matter or extract thereof upon mixing of inexpensive raw materials such as magnesium sulfate. The invention also provides a method for producing PAPS from inexpensive raw materials. The methods involve preparing a transformant (a) of a bacterium of the genus, which contains a gene encoding an ATP sulfurylase and a gene encoding an APS kinase, which are expressible, and in which a cell plasma membrane of the transformant (a) is substance-permeable, or a treated matter of the transformant (a), and conducting a reaction for producing PAPS by using a reaction solution containing ATP or an ATP source, a sulfate ion source, and the transformant (a) or the treated matter thereof.