The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 01, 2025

Filed:

Jun. 26, 2019
Applicant:

Altius Institute for Biomedical Sciences, Seattle, WA (US);

Inventors:

John A. Stamatoyannopoulos, Seattle, WA (US);

Fyodor Urnov, Seattle, WA (US);

Sean Thomas, Seattle, WA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/195 (2006.01); C12N 9/22 (2006.01); C12N 15/90 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/195 (2013.01); C12N 9/22 (2013.01); C12N 15/907 (2013.01); A61K 38/00 (2013.01); C07K 2319/80 (2013.01); C12N 2800/80 (2013.01);
Abstract

Provided herein are polypeptides, compositions comprising the polypeptides and methods for genome editing and gene regulation (e.g., activation and/or repression) using the polypeptides or the compositions comprising the polypeptides, such as, DNA binding domains derived from the genus of. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a TALE protein, such as, aTALE protein. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a DNA binding protein derived from bacteria of the genus


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