The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2025
Filed:
Mar. 01, 2023
Applicant:
Verve Therapeutics, Inc., Boston, MA (US);
Inventors:
Christopher Cheng, North Reading, MA (US);
Kallanthottathil Rajeev, Wayland, MA (US);
Caroline Reiss, Somerville, MA (US);
Assignee:
Verve Therapeutics, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C12N 9/12 (2006.01); C12P 19/34 (2006.01); A61K 31/7115 (2006.01); A61K 31/712 (2006.01); A61K 31/7125 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C12N 9/1247 (2013.01); C12P 19/34 (2013.01); C12Y 207/07006 (2013.01); A61K 31/7115 (2013.01); A61K 31/712 (2013.01); A61K 31/7125 (2013.01);
Abstract
Provided herein are compositions and methods for preparation of 5' end region-modified mRNAs. In particular, the instant disclosure relates to novel mRNA 5′ end region motifs and sequence initiators therefore together with assays that are capable of measuring the aspects of the functionality of those motifs and sequence initiators. Further provided herein are compositions and methods of treating conditions related to coronary disease.