The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2025
Filed:
Feb. 07, 2024
Applicant:
Geron Corporation, Foster City, CA (US);
Inventors:
Jale Muslehiddinoglu, Beerse, BE;
Dinesh Gala, Beerse, BE;
Jennifer Elizabeth Albaneze-Walker, Beerse, BE;
Assignee:
Geron Corporation, Foster City, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 1/00 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C07H 1/00 (2013.01); C07H 21/04 (2013.01);
Abstract
The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle solid-phase support bound process comprising the steps of deprotection of the 3′-amino group of the support-bound oligonucleotide, coupling with a 5′-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3′-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.