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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12264134 B1

PDFFull Text
Date of Patent:
Apr. 01, 2025

Filed:

Nov. 25, 2019

Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (ido) inhibitors

Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Dane Clausen, Rahway, NJ (US);

Ping Chen, Edison, NJ (US);

Xavier Fradera, Brookline, MA (US);

Liangqin Guo, Monroe Township, NJ (US);

Yongxin Han, Needham, MA (US);

Shuwen He, Fanwood, NJ (US);

Xianhai Huang, Warren, NJ (US);

Joseph Kozlowski, Princeton, NJ (US);

Guoqing Li, Belle Mead, NJ (US);

Theodore A. Martinot, Southborough, MA (US);

Alexander Pasternak, Jamaica Plain, MA (US);

Andreas Verras, New York, NY (US);

Li Xiao, Cranbury, NJ (US);

Feng Ye, Scotch Plains, NJ (US);

Wensheng Yu, Edison, NJ (US);

Rui Zhang, Plainsboro, NJ (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:

Kristi K. Harman

Catherine D. Fitch

Primary Examiner:

Juliet C Switzer

Assistant Examiner:

Dawanna Shar-Day White

Int. Cl.
CPC ...
C07D 231/56 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); C07D 231/54 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01); C07D 491/052 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01); C07D 498/08 (2006.01); C07D 498/10 (2006.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); C07D 231/54 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 491/052 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01); C07D 498/08 (2013.01); C07D 498/10 (2013.01);
Abstract

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

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