The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 01, 2025

Filed:

Feb. 11, 2022
Applicant:

Rampart Health, L.l.c., Orlando, FL (US);

Inventors:

David Granger Bostwick, Orlando, FL (US);

Brian Rafferty Bostwick, Orlando, FL (US);

Peter John Littrup, Bloomfield Hills, MI (US);

Assignee:

Rampart Health, L.L.C., Orlando, FL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61B 18/02 (2006.01); A61K 9/00 (2006.01); A61K 31/675 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61P 35/04 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61B 18/02 (2013.01); A61K 9/0019 (2013.01); A61K 31/675 (2013.01); A61K 38/191 (2013.01); A61K 38/193 (2013.01); A61K 38/2026 (2013.01); A61K 38/204 (2013.01); A61K 38/208 (2013.01); A61K 38/212 (2013.01); A61K 38/217 (2013.01); A61K 39/0011 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); A61K 2039/507 (2013.01); A61K 2039/5152 (2013.01);
Abstract

This invention relates to a therapeutic composition comprising i) at least two immune checkpoint inhibitors, ii) at least one drug selected from a cytokine a cytotoxic or cytostatic chemotherapeutic drug, and combinations thereof, and iii) a cancer vaccine prepared from tumor or cancer cells, or derivatives thereof, that have been prepared through an ex vivo treatment that creates necrotic and/or necroptotic cancer cells while minimizing destruction of cancer antigens. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the therapeutic composition in an amount effective to treat the tumor or cancer.


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