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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12263159 B1

PDFFull Text
Date of Patent:
Apr. 01, 2025

Filed:

Jan. 23, 2024

Fused ring compound having urea structure

Applicant:

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);

Inventors:

Tsuyoshi Nakamura, Tokyo, JP;

Mayuko Akiu, Tokyo, JP;

Takashi Tsuji, Tokyo, JP;

Jun Tanaka, Tokyo, JP;

Koji Terayama, Tokyo, JP;

Mika Yokoyama, Tokyo, JP;

Anthony B. Pinkerton, Rancho Santa Fe, CA (US);

Edward Hampton Sessions, Orlando, FL (US);

Assignee:

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US);

Attorney:

WILSON SONSINI GOODRICH & ROSATI

Primary Examiner:

Alicia L Otton

Assistant Examiner:

David M Shim

Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/422 (2006.01); A61K 31/423 (2006.01); A61K 31/437 (2006.01); A61K 31/443 (2006.01); A61K 31/444 (2006.01); A61K 31/519 (2006.01); A61K 31/538 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); A61P 3/04 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/422 (2013.01); A61K 31/423 (2013.01); A61K 31/437 (2013.01); A61K 31/443 (2013.01); A61K 31/444 (2013.01); A61K 31/519 (2013.01); A61K 31/538 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61P 3/04 (2018.01); A61P 25/28 (2018.01); A61P 27/02 (2018.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 498/08 (2013.01);
Abstract

The present invention relates to a novel fused ring compound having urea structure that exhibits excellent NAMPT activating effect, and a method using the same for treating/preventing metabolic disorder, cardiovascular and kidney disease, mitochondrial disease, neurodegenerative disease, ocular disease, and muscle wasting disorder. The present invention provides a compound represented by following formula (I) or a pharmacologically acceptable salt:

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