The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Feb. 07, 2019
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Andrew Baik, Scarsdale, NY (US);
Katherine Cygnar, New York, NY (US);
Maria Praggastis, Cortlandt Manor, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/26 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 3/00 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2408 (2013.01); A61K 48/005 (2013.01); A61P 3/00 (2018.01); C07K 16/2881 (2013.01); C07K 16/2896 (2013.01); C12Y 302/0102 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2319/33 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Compositions and methods for delivering a therapeutic protein to the central nervous system (CNS), in order to treat diseases and disorders that impair the CNS, such as treating lysosomal storage diseases are disclosed. Therapeutic proteins delivered via a therapeutically effective amount of a nucleotide composition encoding the therapeutic protein conjugated to a cell surface receptor-binding protein that crosses the blood brain barrier (BBB) are provided.