The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 25, 2025

Filed:

Apr. 17, 2023
Applicant:

Scarcell Therapeutics, Paris, FR;

Inventors:

Antoine Lafont, Paris, FR;

Mathieu Castela, Clamart, FR;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2015.01); A61K 9/08 (2006.01); A61K 35/33 (2015.01); A61K 35/38 (2015.01); A61K 45/06 (2006.01); A61P 19/00 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0632 (2013.01); A61K 9/08 (2013.01); A61K 35/28 (2013.01); A61K 35/33 (2013.01); A61K 35/38 (2013.01); A61K 45/06 (2013.01); A61P 19/00 (2018.01); C12N 5/0656 (2013.01); C12N 5/0692 (2013.01); C12N 2500/32 (2013.01); C12N 2500/84 (2013.01); C12N 2501/115 (2013.01); C12N 2501/2301 (2013.01); C12N 2509/00 (2013.01);
Abstract

Compositions of matter, including cell populations and medicaments, are provided that are derived from human gingival fibroblasts and have cell phenotypes that occur in proportions not found in natural gum tissue, but rather, are preferentially are selected to express proteins favoring angiogenesis and anti-inflammatory effects, while reducing cell populations that promote tumorigenicity and/or formation of metalloproteinases that inhibit tissue regeneration. Methods of generating such compositions are provided that increase proliferation many-fold compared to previously known methods, and methods of using such compositions in a wide range of human cell therapies are provided.


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