The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Aug. 29, 2018
Ose Immunotherapeutics, Nantes, FR;
Etablissement Francais Du Sang, La Plaine St Denis, FR;
Assistance Publique—hopitaux DE Paris, Paris, FR;
Bernard Vanhove, Reze, FR;
Nicolas Poirier, Treillieres, FR;
Sebastien Maury, Paris, FR;
Jose Cohen, Paris, FR;
Caroline Pilon, Saint Maurice, FR;
Brigitte Birebent, Yebles, FR;
Ose Immunotherapeutics, Nantes, FR;
Etablissement Francais Du Sang, La Plaine St Denis, FR;
Assistance Publique—Hopitaux De Paris, Paris, FR;
Abstract
The invention relates to methods and preparations for sorting out T effector cells from human leukocytes using anti-CD127 antibodies. Accordingly the invention relates to the use of anti-CD127 antibodies enabling discriminative depletion of subpopulations of Tregulatory cells expressing CD127+ at low levels in a population of human T lymphocytes in order to enable the use of the recovered selected cell preparations comprising essentially Teffector cells as lymphocytes and preferably devoid of Tregulatory cells, for improved efficacy in particular when administered to a patient for therapy.