The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Jun. 09, 2021
Applicant:
Tiga Tx, Inc., Westerly, RI (US);
Inventors:
Jeanette Henrica Wilhelmina Leusen, Utrecht, NL;
Johannes Gerardus Maria Evers, Utrecht, NL;
Geert Jan Van Tetering, Utrecht, NL;
Assignee:
TigaTX, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/42 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/4283 (2013.01); C07K 16/283 (2013.01); C07K 16/2887 (2013.01); A61K 2039/505 (2013.01); C07K 2317/41 (2013.01); C07K 2317/51 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/94 (2013.01);
Abstract
Provided herein are engineered antibodies that comprise a modified IgA2 heavy chain constant region, pharmaceutical compositions, and methods of use. The engineered antibodies described herein comprise one or more amino acid substitutions or deletions in a constant region of an IgA2 domain that modify naturally occurring glycosylation site(s). Further provided herein are methods of treating disorders, including cancer, by administering an engineered IgA antibody described herein.