The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Dec. 27, 2019
Nanjing Genscript Biotech Co., Ltd., Nanjing, CN;
Nanjing Legend Biotech Co., Ltd., Nanjing, CN;
Liusong Yin, Nanjing, CN;
Tielin Zhou, Singapore, SG;
Zhuo Fang, Nanjing, CN;
Yong Liu, Nanjing, CN;
Qiuchuan Zhuang, Nanjing, CN;
Bo Wu, Nanjing, CN;
Xiaohu Fan, Nanjing, CN;
Qingshan Zhang, Nanjing, CN;
Dan Zhao, Nanjing, CN;
Jie Mao, Nanjing, CN;
Nanjing GenScript Biotech Co., Ltd., Nanjing, CN;
Nanjing Legend Biotech Co., Ltd, Nanjing, CN;
Abstract
Described herein are binding moieties, such as antibodies, that specifically bind Claudin18.2, and chimeric antigen receptors comprising such binding moieties. Further provided are engineered immune cells (such as T cells) comprising anti-Claudin 18.2 chimeric antigen receptors. Also disclosed are methods of treating Claudin18.2-expressing tumor or cancers using the binding moieties, chimeric antigen receptors and engineered immune cells.