The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 25, 2025

Filed:

Jul. 30, 2020
Applicant:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Inventors:

Laura Deak Codarri, Schlieren, CH;

Stefan Dengl, Penzberg, DE;

Jens Fischer, Penzberg, DE;

Thomas Hofer, Schlieren, CH;

Laurent Lariviere, Penzberg, DE;

Ekkehard Moessner, Schlieren, CH;

Stefan Seeber, Penzberg, DE;

Pablo Umana, Schlieren, CH;

Anne-Claire Zagdoun, Schlieren, CH;

Assignee:

Hoffman-La Roche Inc., Little Falls, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 1/04 (2006.01); C07K 16/30 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 1/047 (2013.01); C07K 16/2803 (2013.01); C07K 16/2818 (2013.01); C07K 16/2881 (2013.01); C07K 16/3007 (2013.01); C07K 16/3053 (2013.01); C07K 16/40 (2013.01); C07K 2317/21 (2013.01); C07K 2317/56 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract

The invention relates autonomous VH domains (aVH) with cysteines in positions 52a and 71 or in positions 33 and 52 in order to stabilize the autonomous VH domains. Said cysteines are capable of forming a disulfide bond and/or form a disulfide bond under suitable conditions. The invention further relates to aVH libraries.


Find Patent Forward Citations

Deak Codarri, Laura. (2025). Stabilized immunoglobulin domains (U.S. Patent No. 12258371). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12258371

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…