The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Jul. 30, 2020
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Laura Deak Codarri, Schlieren, CH;
Stefan Dengl, Penzberg, DE;
Jens Fischer, Penzberg, DE;
Thomas Hofer, Schlieren, CH;
Laurent Lariviere, Penzberg, DE;
Ekkehard Moessner, Schlieren, CH;
Stefan Seeber, Penzberg, DE;
Pablo Umana, Schlieren, CH;
Anne-Claire Zagdoun, Schlieren, CH;
Assignee:
Hoffman-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 1/04 (2006.01); C07K 16/30 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 1/047 (2013.01); C07K 16/2803 (2013.01); C07K 16/2818 (2013.01); C07K 16/2881 (2013.01); C07K 16/3007 (2013.01); C07K 16/3053 (2013.01); C07K 16/40 (2013.01); C07K 2317/21 (2013.01); C07K 2317/56 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The invention relates autonomous VH domains (aVH) with cysteines in positions 52a and 71 or in positions 33 and 52 in order to stabilize the autonomous VH domains. Said cysteines are capable of forming a disulfide bond and/or form a disulfide bond under suitable conditions. The invention further relates to aVH libraries.