The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Apr. 24, 2018
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Jian Hua Gu, Thousand Oaks, CA (US);
Robert Matthew Fesinmeyer, Newbury Park, CA (US);
Rulin Qian, Newbury Park, CA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/08 (2006.01); A61K 9/19 (2006.01); A61K 47/18 (2017.01); C07K 16/24 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
A61K 9/08 (2013.01); A61K 9/19 (2013.01); A61K 47/183 (2013.01); C07K 16/244 (2013.01); C07K 16/40 (2013.01);
Abstract
This invention concerns a series of excipients capable of effectively reducing the viscosity of protein formulations. The viscosity reducing excipients are oligopeptides (e.g., dipeptides, tripeptides) comprising at least one arginine. The peptides may also include basic or acidic or hydrophilic or hydrophobic/aromatic amino acids. An arginine residue may be either at the amino or the carboxyl end of the oligopeptide.