The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 25, 2025

Filed:

Sep. 09, 2022
Applicant:

Hikma Pharmaceuticals Usa Inc., Berkeley Heights, NJ (US);

Inventors:

David E. McAnany, Berkeley Heights, NJ (US);

Michael G. Parker, Berkeley Heights, NJ (US);

Sarah D. Mccue, Berkeley Heights, NJ (US);

Assignee:

Hikma Pharmaceuticals USA Inc., Berkeley Heights, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61J 1/06 (2006.01); A61K 9/08 (2006.01); A61K 31/137 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); B65B 3/00 (2006.01); B65B 7/16 (2006.01); B65B 55/06 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0019 (2013.01); A61J 1/06 (2013.01); A61K 9/08 (2013.01); A61K 31/137 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); B65B 3/003 (2013.01); B65B 7/16 (2013.01); B65B 55/06 (2013.01);
Abstract

This invention relates to a dilute, ready-to-use solution of phenylephrine hydrochloride having improved stability and utility. In a particular embodiment, the formulation consists of an injectable form of phenylephrine hydrochloride with edetate disodium chelating agent in place of any sodium metabisulfite antioxidants to improve the solution's ability to remain stable and active in a dilute state after prolonged storage. This invention also relates to a form for injection of the solution that includes packaging the solution in a single-use container, as well as a form for containing the ready-to-use solution in a sterile, sealed container. Lastly this invention relates to methods of making the injectable solution for use in a single-use container, as well as for containment in a sterile, sealed container.


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