The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
May. 23, 2022
Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
Applicants:
Newcastle University, Newcastle Upon Tyne, GB;
University of Heidelberg, Heidelberg, DE;
Inventors:
Hanns Lochmuller, Newcastle Upon Tyne, GB;
Oliver Muller, Heidelberg, DE;
Assignees:
Newcastle University, Newcastle, GB;
University of Heidelberg, Heidelberg, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 48/0075 (2013.01);
Abstract
The invention provides gene therapy vectors, such as adeno-associated virus (AAV) vectors, expressing a functional fragment of the miniaturized human micro-dystrophin gene and method of using these vectors to express the fragment of micro-dystrophin in skeletal muscles including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy.