The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Nov. 12, 2019
Tianjin Institute of Pharmaceutical Research Co., Ltd., Tianjin, CN;
Yingmei Han, Tianjin, CN;
Wei Liu, Tianjin, CN;
Bingni Liu, Tianjin, CN;
Weiling Kong, Tianjin, CN;
Naxia Zhao, Tianjin, CN;
Guangping Xia, Tianjin, CN;
Qian Shang, Tianjin, CN;
Xiaohua Kong, Tianjin, CN;
Jing Jin, Tianjin, CN;
Yuquan Li, Tianjin, CN;
Xuyuan Liu, Tianjin, CN;
Tianjin Institute of Pharmaceutical Research Co., Ltd., Tianjin, CN;
Abstract
Provided are a polypeptide derivative, modified derivative or salt thereof, and use of the polypeptide derivative, modified derivative or salt thereof, wherein the polypeptide derivative, modified derivative or salt thereof comprises a polypeptide having the sequence of following general formula I, general formula I: wherein the definitions of X, X, X, X, X, X, X, X, X, X, X, X, X, Xand Xare consistent with the definitions in the claims and the description. The polypeptide derivative provided by the invention has a dual agonistic effect on GC/GLP-1 receptors, so that a synergistic effect on energy metabolism is generated, which can effectively reduce blood glucose while reducing body weight and improving the body fat level, and the efficacy is better than that of a single GLP-1 receptor agonist.