The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2025
Filed:
Jul. 19, 2022
Applicant:
Salk Institute for Biological Studies, La Jolla, CA (US);
Inventors:
Sagar P. Bapat, La Jolla, CA (US);
Ye Zheng, La Jolla, CA (US);
Ronald Evans, La Jolla, CA (US);
Michael Downes, La Jolla, CA (US);
Annette R. Atkins, La Jolla, CA (US);
Ruth T. Yu, La Jolla, CA (US);
Assignee:
Salk Institute for Biological Studies, La Jolla, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 3/10 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6883 (2018.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6869 (2013.01); A61K 39/395 (2013.01); A61P 3/10 (2018.01); C07K 16/28 (2013.01); C07K 16/2866 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6883 (2013.01); G01N 33/53 (2013.01); A61K 2039/505 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/7155 (2013.01); G01N 2800/042 (2013.01); G01N 2800/50 (2013.01);
Abstract
The invention features compositions and methods treating or preventing for age-related insulin resistance, type 2 diabetes and related disorders. The method involves depleting fTreg cells with an anti-ST2 antibody to decrease age-related fTreg accumulation and restore insulin sensitivity, thereby treating age-related insulin resistance, type 2 diabetes and related disorders.