The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2025

Filed:

Apr. 03, 2018
Applicants:

Deborah Lynn Greene Nguyen, San Diego, CA (US);

Dwayne E. Carter, San Diego, CA (US);

Rhiannon Hardwick, San Diego, CA (US);

Alice Chen Walters, San Diego, CA (US);

Sharon C. Presnell, Poway, CA (US);

Chirag B. Khatiwala, San Diego, CA (US);

Rami Nasrallah, San Diego, CA (US);

Inventors:

Deborah Lynn Greene Nguyen, San Diego, CA (US);

Dwayne E. Carter, San Diego, CA (US);

Rhiannon Hardwick, San Diego, CA (US);

Alice Chen Walters, San Diego, CA (US);

Sharon C. Presnell, Poway, CA (US);

Chirag B. Khatiwala, San Diego, CA (US);

Rami Nasrallah, San Diego, CA (US);

Assignee:

Organovo, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); G09B 23/30 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0671 (2013.01); G01N 33/5082 (2013.01); G01N 33/6893 (2013.01); G09B 23/306 (2013.01); C12N 2502/1157 (2013.01); C12N 2502/1305 (2013.01); C12N 2502/14 (2013.01); C12N 2503/04 (2013.01); C12N 2513/00 (2013.01); C12N 2533/00 (2013.01); C12N 2535/00 (2013.01); G01N 2800/085 (2013.01); G01N 2800/52 (2013.01);
Abstract

The invention is directed to three-dimensional, engineered, bioprinted biological tissue constructs exhibiting a liver disorder, methods of making the constructs, and use of the constructs in assays, such as drug testing and molecular diagnostic testing, including methods of assessing the ability of a candidate therapeutic agent to reverse, reduce, or prevent a liver disorder, and methods for biomarker discovery.


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