The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2025
Filed:
Jun. 01, 2021
Applicants:
University of Massachusetts, Westborough, MA (US);
Voyager Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Robert M. Kotin, Worcester, MA (US);
Sylvain Cecchini, Worcester, MA (US);
Assignees:
University of Massachusetts, Westborough, MA (US);
Voyager Therapeutics, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 3/00 (2006.01); A61P 3/08 (2006.01); A61P 7/04 (2006.01); A61P 11/12 (2006.01); A61P 27/02 (2006.01); C07K 14/005 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01); C12N 15/64 (2006.01); C12N 15/66 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 48/005 (2013.01); A61K 48/0075 (2013.01); A61P 1/16 (2018.01); A61P 3/00 (2018.01); A61P 3/08 (2018.01); A61P 7/04 (2018.01); A61P 11/12 (2018.01); A61P 27/02 (2018.01); C07K 14/005 (2013.01); C12N 15/09 (2013.01); C12N 15/63 (2013.01); C12N 15/64 (2013.01); C12N 15/66 (2013.01); A61K 48/00 (2013.01); C12N 2710/14043 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01);
Abstract
Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise-symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncated cross-arm sequence. Methods of delivering the nucleic acid to a cell are also provided.