The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2025
Filed:
Sep. 12, 2019
Shihuida Pharmaceutical Group (Jilin) Co., Ltd., Baishan, CN;
Xin Zhang, Suzhou, CN;
Jianjian Peng, Suzhou, CN;
Kai Fu, Suzhou, CN;
Hui Ma, Suzhou, CN;
Xiaolong Pan, Suzhou, CN;
Shilong Fu, Suzhou, CN;
Shuli Ma, Suzhou, CN;
Jian Ding, Suzhou, CN;
Shihuida Pharmaceutical Group (Jilin) Co., Ltd., Baishan, CN;
Abstract
An antibody may be capable of specifically binding CD137 or an antigen binding fragment thereof, wherein the light chain variable region and the heavy chain variable region have one or more mutations. The antibody or antigen binding fragment thereof may be used in preparing a drug. The antibody or an antigen binding fragment thereof may specifically bind CD137, and may include a light chain variable region VL and a heavy chain variable region VH, wherein compared to a sequence as shown in SEQ ID NO: 103, the VL comprises one or more VL amino acid mutations, and the VL amino acid mutation occurs at one or more positions: V3, A10, K44, D71, and/or V77.